{"id":5183,"date":"2025-09-30T05:47:13","date_gmt":"2025-09-30T05:47:13","guid":{"rendered":"https:\/\/sofiatechlabs.bg\/laboratory\/in-vitro-laboratory-for-evaluation-of-biological-activity-and-toxicity\/"},"modified":"2025-12-13T10:36:53","modified_gmt":"2025-12-13T10:36:53","slug":"in-vitro-laboratory-for-evaluation-of-biological-activity-and-toxicity","status":"publish","type":"labs","link":"https:\/\/sofiatechlabs.bg\/en\/laboratory\/in-vitro-laboratory-for-evaluation-of-biological-activity-and-toxicity\/","title":{"rendered":"In vitro Laboratory for Evaluation of Biological Activity and Toxicity"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-post\" data-elementor-id=\"5183\" class=\"elementor elementor-5183 elementor-62\" data-elementor-post-type=\"labs\">\n\t\t\t\t<div class=\"elementor-element elementor-element-1ed0456 e-flex e-con-boxed e-con e-parent\" data-id=\"1ed0456\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;video&quot;,&quot;background_video_link&quot;:&quot;\\\/wp-content\\\/uploads\\\/2025\\\/09\\\/Invitro.mp4&quot;,&quot;background_play_on_mobile&quot;:&quot;yes&quot;}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-background-video-container\">\n\t\t\t\t\t\t\t<video class=\"elementor-background-video-hosted\" role=\"presentation\" autoplay muted playsinline loop><\/video>\n\t\t\t\t\t<\/div>\t\t<div class=\"elementor-element elementor-element-b43e5e9 elementor-invisible elementor-widget elementor-widget-image\" data-id=\"b43e5e9\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeInUp&quot;}\" data-widget_type=\"image.default\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" width=\"234\" height=\"57\" src=\"https:\/\/sofiatechlabs.bg\/wp-content\/uploads\/2025\/10\/Logo-invitro-1.svg\" class=\"attachment-medium size-medium wp-image-3445\" alt=\"\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-5b137d0 elementor-invisible elementor-widget elementor-widget-heading\" data-id=\"5b137d0\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeInLeft&quot;}\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">In vitro Laboratory <br>for Evaluation of Biological <br>Activity and Toxicity<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-127522b elementor-invisible elementor-widget elementor-widget-text-editor\" data-id=\"127522b\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeInRight&quot;}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p>The laboratory is equipped with modern specialized instruments and equipment in the fields of cell biology, DNA analysis, and microbiology.<br \/>In addition, ecotoxicological studies, experiments with plant cultures, and pathomorphological analyses on human and animal cell lines are carried out.<\/p>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-f9b83aa e-flex e-con-boxed e-con e-parent\" data-id=\"f9b83aa\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;gradient&quot;,&quot;animation&quot;:&quot;none&quot;}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-2736ffa e-con-full e-flex elementor-invisible e-con e-child\" data-id=\"2736ffa\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;animation&quot;:&quot;fadeInUp&quot;}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-3425359 elementor-invisible elementor-widget elementor-widget-heading\" data-id=\"3425359\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Services provided<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-39ca9e9 list-goals elementor-invisible elementor-widget elementor-widget-text-editor\" data-id=\"39ca9e9\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeInUp&quot;}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<ul>\n<li>Storage and maintenance of a microorganism collection;<\/li>\n<li>Isolation of mononuclear cells, including sample processing, cell and\/or biological component isolation, storage, additional processing for research purposes, and result validation. The implementation of laboratory protocols ensures high cell viability and purity, required for subsequent molecular and functional analyses;<\/li>\n<li>In vitro testing of cytotoxicity, \/biocompatibility, antioxidant, and antineoplastic activity of biologically active substances on human and animal cell lines. Molecular and cellular techniques are applied to assess viability, proliferation, apoptosis, and metabolism, with options for customized studies of plant extracts, novel compounds, drug candidates, cosmetic products, and biomaterials;<\/li>\n<li>Development of individual experimental projects in accordance with good laboratory practices, including preliminary research, formulation of hypotheses and objectives, planning and design of the scientific study, experiment execution, and result analysis and discussion;<\/li>\n<li>Testing of microbiological indicators in cosmetic products, plant extracts, essential oils, and chemical compounds. Characterization and evaluation of antimicrobial activity of various types of extracts, formulations, newly synthesized structures, chiral compounds, derivatives of natural terpenoids, and others, through validated analyses and an interdisciplinary approach;<\/li>\n<li>Evaluation of preservative efficacy using standardized methods compliant with regulatory requirements and established laboratory practices. The analysis includes assessment of preservative ability to prevent microbial growth in various matrices, ensuring product safety and stability. This service is suitable for the cosmetic, pharmaceutical, and food industries.<\/li>\n<\/ul>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-c96fd31 e-flex e-con-boxed e-con e-parent\" data-id=\"c96fd31\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;gradient&quot;}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-be6a480 elementor-invisible elementor-widget elementor-widget-heading\" data-id=\"be6a480\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Activities <\/h2>\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-3bb6143 e-grid e-con-full grid-title elementor-invisible e-con e-child\" data-id=\"3bb6143\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;animation&quot;:&quot;fadeInUp&quot;}\">\n\t\t<div class=\"elementor-element elementor-element-0fab49d e-con-full e-flex e-con e-child\" data-id=\"0fab49d\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-5ca5811 elementor-widget elementor-widget-text-editor\" data-id=\"5ca5811\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p>Study of specific probiotic properties and characteristics of potential probiotic strains within the Lactobacillus genus. Optimization of fermentation conditions of lactic acid bacteria aimed at producing cell biomass and culture filtrates for the development of probiotic and antimicrobial products;<\/p>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-df805bf e-con-full e-flex e-con e-child\" data-id=\"df805bf\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-7c3bbcb elementor-widget elementor-widget-text-editor\" data-id=\"7c3bbcb\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p>In vitro propagation and maintenance of plant cell and tissue cultures of valuable cell lines from valuable medicinal and aromatic plants. Development of methods for efficient and sustainable cultivation of plant cells and tissues through optimization of growth conditions, selection of specific nutrient media, regulation of light and temperature regimes, and application of biostimulators. Investigation of the ability of cell cultures to synthesize bioactive compounds, including antioxidants, essential oils, and secondary metabolites of pharmacological significance;<\/p>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-ad9c24b e-con-full e-flex e-con e-child\" data-id=\"ad9c24b\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-715cad9 elementor-widget elementor-widget-text-editor\" data-id=\"715cad9\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\tProduction of cell biomass from lactic acid bacteria and culture filtrates for the development of probiotic and antimicrobial products. Study of the stability and storage of the obtained products, including resistance of the cell biomass and culture filtrate to various stress conditions. Evaluation of biocompatibility and probiotic activity using in vitro models to confirm their safety and biological effectiveness;<br>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-f478cc4 e-con-full e-flex e-con e-child\" data-id=\"f478cc4\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-93f2087 elementor-widget elementor-widget-text-editor\" data-id=\"93f2087\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p>Application of yeast and fungal fermentations to modify the composition and utilize wastewater from rose oil distillation, rich in phenolic compounds. Study of suitable yeast and fungal species with high metabolic activity for the production of bioactive metabolites;<\/p>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-c5dfd7d e-con-full e-flex e-con e-child\" data-id=\"c5dfd7d\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-c967a67 elementor-widget elementor-widget-text-editor\" data-id=\"c967a67\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p>Development of sustainable and economically efficient technologies for the utilization of waste products, which simultaneously reduce the environmental impact footprint and create added value;<\/p>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-b50a1b5 e-con-full e-flex e-con e-child\" data-id=\"b50a1b5\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-f802d3f elementor-widget elementor-widget-text-editor\" data-id=\"f802d3f\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p>Isolation and characterization of human stem cells, comparative studies on methods for isolation, cultivation, differentiation, and cryopreservation of stem cells using established laboratory practices. Development of innovative cryopreservation protocols for long-term cell storage at extremely low temperatures, aimed at preserving their viability and biological activity;<\/p>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-234430b e-con-full e-flex e-con e-child\" data-id=\"234430b\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-13403cf elementor-widget elementor-widget-text-editor\" data-id=\"13403cf\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p>Application of recombinant DNA methods, molecular markers, and genotyping, as well as gene expression analysis. Study of various molecular markers and microsatellites to identify genetic variations and their relationship with phenotypic characteristics. Evaluation of interactions between genetic and epigenetic factors in the regulation of gene expression and their significance;<\/p>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-fd11593 e-con-full e-flex e-con e-child\" data-id=\"fd11593\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-77e203d elementor-widget elementor-widget-text-editor\" data-id=\"77e203d\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p>Ecotoxicological testing and evaluation of various industrial products, wastes, biologically active extracts, and compounds. Use of modern bioindicators, such as plant, animal, and microbial models, for studying acute and chronic toxic effects;<\/p>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-743ebb6 e-con-full e-flex e-con e-child\" data-id=\"743ebb6\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-0ab681a elementor-widget elementor-widget-text-editor\" data-id=\"0ab681a\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p>Determination of antimicrobial activity of plant extracts, essential oils, chemical compounds, and biologically active molecules against reference pathogenic microorganisms through validated assays and an interdisciplinary approach for accurate evaluation and validation of 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.elementor-element.elementor-element-c02271a{font-family:\"Geologica\", Sans-serif;font-size:16px;font-weight:100;line-height:24px;}@media(max-width:1366px){.elementor-widget-theme-post-content{font-size:var( --e-global-typography-text-font-size );line-height:var( --e-global-typography-text-line-height );}}@media(max-width:1024px){.elementor-5376 .elementor-element.elementor-element-2f021c3 .elementor-heading-title{font-size:16px;line-height:24px;}.elementor-widget-theme-post-content{font-size:var( --e-global-typography-text-font-size );line-height:var( --e-global-typography-text-line-height );}.elementor-5376 .elementor-element.elementor-element-c02271a{line-height:24px;}}@media(max-width:880px){.elementor-5376 .elementor-element.elementor-element-5ab9a7b{--padding-top:30px;--padding-bottom:30px;--padding-left:30px;--padding-right:30px;}}@media(max-width:767px){.elementor-5376 .elementor-element.elementor-element-5ab9a7b{--padding-top:30px;--padding-bottom:20px;--padding-left:20px;--padding-right:20px;}.elementor-widget-theme-post-content{font-size:var( --e-global-typography-text-font-size );line-height:var( --e-global-typography-text-line-height );}}<\/style>\t\t<div data-elementor-type=\"loop-item\" data-elementor-id=\"5376\" class=\"elementor elementor-5376 elementor-1960 e-loop-item e-loop-item-5078 post-5078 publication type-publication status-publish format-standard hentry project_project-in-vitro-lab\" data-elementor-post-type=\"elementor_library\" data-custom-edit-handle=\"1\">\n\t\t\t<div class=\"elementor-element elementor-element-5ab9a7b e-con-full e-flex e-con e-parent\" data-id=\"5ab9a7b\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-2f021c3 elementor-widget elementor-widget-theme-post-title elementor-page-title elementor-widget-heading\" data-id=\"2f021c3\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"theme-post-title.default\">\n\t\t\t\t\t<h6 class=\"elementor-heading-title elementor-size-default\">The Antioxidant Properties of Extracts of Cuscuta spp. Depend on the Parasite and the Host Species:<\/h6>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-c02271a elementor-widget elementor-widget-theme-post-content\" data-id=\"c02271a\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"theme-post-content.default\">\n\t\t\t\t\t\n<p class=\"wp-block-paragraph\">Lozanova, V.; Teofanova, D.; Chakarova, B.; Rusanov, K.; Pachedjieva, K.; Tosheva, A.; Zagorcheva, T.; Zagorchev, Antioxidants 2025, 14, 761;<\/p>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div data-elementor-type=\"loop-item\" data-elementor-id=\"5376\" class=\"elementor elementor-5376 elementor-1960 e-loop-item e-loop-item-5157 post-5157 publication type-publication status-publish format-standard hentry project_project-in-vitro-lab\" data-elementor-post-type=\"elementor_library\" data-custom-edit-handle=\"1\">\n\t\t\t<div class=\"elementor-element elementor-element-5ab9a7b e-con-full e-flex e-con e-parent\" data-id=\"5ab9a7b\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-2f021c3 elementor-widget elementor-widget-theme-post-title elementor-page-title elementor-widget-heading\" data-id=\"2f021c3\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"theme-post-title.default\">\n\t\t\t\t\t<h6 class=\"elementor-heading-title elementor-size-default\">Analysis of Variations in the Flavonoid Profiles of Cuscuta campestris and Cuscuta epithymum in Bulgaria as a Potential Chemotaxonomical Marker<\/h6>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-c02271a elementor-widget elementor-widget-theme-post-content\" data-id=\"c02271a\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"theme-post-content.default\">\n\t\t\t\t\t\n<p class=\"wp-block-paragraph\">Bilyana Chakarova 1,2, Lyuben Zagorchev 1,* Kalina Pachedjieva 1, Anita Tosheva 1, Tzvetelina Zagorcheva 2,3, Krasimir Rusanov 2,4 and Denitsa Teofanova, Plants 2025, 14, 1220;<\/p>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div data-elementor-type=\"loop-item\" data-elementor-id=\"5376\" class=\"elementor elementor-5376 elementor-1960 e-loop-item e-loop-item-5118 post-5118 publication type-publication status-publish format-standard hentry project_project-in-vitro-lab\" data-elementor-post-type=\"elementor_library\" data-custom-edit-handle=\"1\">\n\t\t\t<div class=\"elementor-element elementor-element-5ab9a7b e-con-full e-flex e-con e-parent\" data-id=\"5ab9a7b\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-2f021c3 elementor-widget elementor-widget-theme-post-title elementor-page-title elementor-widget-heading\" data-id=\"2f021c3\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"theme-post-title.default\">\n\t\t\t\t\t<h6 class=\"elementor-heading-title elementor-size-default\">In Vitro Biological Activity a Polyphenol of Rose Oil Distillation Waste Water and Rose Oil of Rosa Damascena;<\/h6>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-c02271a elementor-widget elementor-widget-theme-post-content\" data-id=\"c02271a\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"theme-post-content.default\">\n\t\t\t\t\t\n<p class=\"wp-block-paragraph\">Boyka Andonova-Lilova, Mila Rusanova, Krasimir Rusanov, Tzvetelina Zagorcheva, Ivan Atanasov, 2023, IV INTERNATIONAL GREEN BIOTECHNOLOGY CONGRESS, 7-8 November, Sofia, Bulgaria;<\/p>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div data-elementor-type=\"loop-item\" data-elementor-id=\"5376\" class=\"elementor elementor-5376 elementor-1960 e-loop-item e-loop-item-5084 post-5084 publication type-publication status-publish format-standard hentry project_project-in-vitro-lab\" data-elementor-post-type=\"elementor_library\" data-custom-edit-handle=\"1\">\n\t\t\t<div class=\"elementor-element elementor-element-5ab9a7b e-con-full e-flex e-con e-parent\" data-id=\"5ab9a7b\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-2f021c3 elementor-widget elementor-widget-theme-post-title elementor-page-title elementor-widget-heading\" data-id=\"2f021c3\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"theme-post-title.default\">\n\t\t\t\t\t<h6 class=\"elementor-heading-title elementor-size-default\">Chemical characterization and biological activity of Melissa officinalis extracts from dried plant and solid waste from essential oil industry;<\/h6>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-c02271a elementor-widget elementor-widget-theme-post-content\" data-id=\"c02271a\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"theme-post-content.default\">\n\t\t\t\t\t\n<p class=\"wp-block-paragraph\">M. Kamenova-Nacheva, P. Staleva, M. Tavlinova-Kirilova, S. Momchilova, A. Trendafilova, B. Andonova-Lilova, M. Rusanova, T. Zagorcheva, V. Ruseva, I. Atanassov, V. Dimitrov; Planta Medica, December 2022, Volume 88, Issue 15, 2022;<\/p>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div data-elementor-type=\"loop-item\" data-elementor-id=\"5376\" class=\"elementor elementor-5376 elementor-1960 e-loop-item e-loop-item-5109 post-5109 publication type-publication status-publish format-standard hentry project_project-in-vitro-lab\" data-elementor-post-type=\"elementor_library\" data-custom-edit-handle=\"1\">\n\t\t\t<div class=\"elementor-element elementor-element-5ab9a7b e-con-full e-flex e-con e-parent\" data-id=\"5ab9a7b\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-2f021c3 elementor-widget elementor-widget-theme-post-title elementor-page-title elementor-widget-heading\" data-id=\"2f021c3\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"theme-post-title.default\">\n\t\t\t\t\t<h6 class=\"elementor-heading-title elementor-size-default\">Fermentation of rose oil distillation waste waters and biotransformation of phenolics by Trichoderma asperellum SL-45;<\/h6>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-c02271a elementor-widget elementor-widget-theme-post-content\" data-id=\"c02271a\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"theme-post-content.default\">\n\t\t\t\t\t\n<p class=\"wp-block-paragraph\">\u041c. Rusanova, K. Rusanov, S. Momchilova, T. Zagorcheva, Y. Evstatieva, D. Nikolova, I. Atanassov; Annuaire de l\u2019Universite de Sofia \u201cSt. Kliment Ohridski\u201d, submitted for publication in 2019;<\/p>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<span class=\"e-load-more-spinner\">\n\t\t\t\t<svg aria-hidden=\"true\" class=\"e-font-icon-svg e-fas-spinner\" viewBox=\"0 0 512 512\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path d=\"M304 48c0 26.51-21.49 48-48 48s-48-21.49-48-48 21.49-48 48-48 48 21.49 48 48zm-48 368c-26.51 0-48 21.49-48 48s21.49 48 48 48 48-21.49 48-48-21.49-48-48-48zm208-208c-26.51 0-48 21.49-48 48s21.49 48 48 48 48-21.49 48-48-21.49-48-48-48zM96 256c0-26.51-21.49-48-48-48S0 229.49 0 256s21.49 48 48 48 48-21.49 48-48zm12.922 99.078c-26.51 0-48 21.49-48 48s21.49 48 48 48 48-21.49 48-48c0-26.509-21.491-48-48-48zm294.156 0c-26.51 0-48 21.49-48 48s21.49 48 48 48 48-21.49 48-48c0-26.509-21.49-48-48-48zM108.922 60.922c-26.51 0-48 21.49-48 48s21.49 48 48 48 48-21.49 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elementor-element-f77c5d9 e-flex e-con-boxed elementor-invisible e-con e-parent\" data-id=\"f77c5d9\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;animation&quot;:&quot;fadeInUp&quot;}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-3993b62 e-con-full e-flex e-con e-child\" data-id=\"3993b62\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-fe7e2e8 ulli-block elementor-widget elementor-widget-text-editor\" data-id=\"fe7e2e8\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<ul>\r\n \t<li>Multi-mode hybrid system for assessing toxicity and mechanisms of action of biologically active substances on cellular model systems \u2013 Cell Imaging Multi-Mode Reader (Cytation 3);<\/li>\r\n \t<li>Bioreactor for parallel cultivation \u2013 Multifors 2;<\/li>\r\n \t<li>Class 2 laminar flow hood;<\/li>\r\n \t<li>Multi-gas CO\u2082\/O\u2082\/N\u2082 incubator;<\/li>\r\n \t<li>Laboratory ultra-low temperature freezer -150\u00b0C;<\/li>\r\n \t<li>Automated anaerobic chamber;<\/li>\r\n<li>Lyophilizer (freeze dryer);<\/li>\r\n<\/ul>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-e7fa11c e-con-full e-flex e-con e-child\" data-id=\"e7fa11c\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-7364650 ulli-block elementor-widget elementor-widget-text-editor\" data-id=\"7364650\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<ul> \t\r\n \t<li>Analytical balance;<\/li>\r\n \t<li>Fluorescent microplate reader;<\/li>\r\n \t<li>UV\/Vis microplate reader;<\/li>\r\n \t<li>Fast protein liquid chromatography system (FPLC);<\/li>\r\n \t<li>Flow cytometer;<\/li>\r\n \t<li>Gradient PCR machine;<\/li>\r\n \t<li>Real-time PCR (qPCR) machine;<\/li>\r\n \t<li>Biological upright trinocular fluorescence microscope;<\/li>\r\n<\/ul>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-688f1bf e-flex e-con-boxed e-con e-parent\" data-id=\"688f1bf\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-f6dd53f bgr-plus-line elementor-widget elementor-widget-html\" data-id=\"f6dd53f\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"html.default\">\n\t\t\t\t\t  <div class=\"axis-container\">\r\n    <div class=\"cross\"><svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"58\" height=\"58\" viewBox=\"0 0 58 58\">\r\n  <g id=\"Group_111\" data-name=\"Group 111\" transform=\"translate(-812 -1109)\">\r\n    <g id=\"Group_111-2\" data-name=\"Group 111\" transform=\"translate(812 1138) rotate(-90)\">\r\n 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112\" transform=\"translate(841 1109)\">\r\n      <line id=\"Line_8-2\" data-name=\"Line 8\" y2=\"21\" transform=\"translate(0 0)\" fill=\"none\" stroke=\"#707070\" stroke-width=\"1\"\/>\r\n      <line id=\"Line_9-2\" data-name=\"Line 9\" y2=\"21\" transform=\"translate(0 37)\" fill=\"none\" stroke=\"#707070\" stroke-width=\"1\"\/>\r\n    <\/g>\r\n  <\/g>\r\n<\/svg><\/div>\r\n  <\/div>\r\n    <style>\r\n    .axis-container {\r\n      display: flex;\r\n      align-items: center;\r\n      width: 100%;\r\n      margin: 1rem auto;\r\n      padding: 0 1rem;\r\n      box-sizing: border-box;\r\n    }\r\n\r\n\r\n\r\n    .line {\r\n      flex: 1;\r\n      height: 1.3px; \r\n      background-color:#383838;\r\n      margin: -4.5px 0.5rem 0 0.5rem; \r\n    }\r\n\r\n\r\n  <\/style>\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-6cd28fb e-flex e-con-boxed elementor-invisible e-con e-parent\" data-id=\"6cd28fb\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;animation&quot;:&quot;fadeIn&quot;}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-2cd0e04 elementor-invisible elementor-widget elementor-widget-heading\" data-id=\"2cd0e04\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Management<\/h2>\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-3d117f6 e-con-full e-flex e-con e-child\" data-id=\"3d117f6\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t<div class=\"elementor-element elementor-element-73a75fd e-con-full e-flex e-con e-child\" data-id=\"73a75fd\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-49ed0c4 elementor-widget elementor-widget-image\" data-id=\"49ed0c4\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img fetchpriority=\"high\" decoding=\"async\" width=\"395\" height=\"395\" src=\"https:\/\/sofiatechlabs.bg\/wp-content\/uploads\/2025\/10\/Lab-manager.jpg\" class=\"attachment-large size-large wp-image-559\" alt=\"\" srcset=\"https:\/\/sofiatechlabs.bg\/wp-content\/uploads\/2025\/10\/Lab-manager.jpg 395w, https:\/\/sofiatechlabs.bg\/wp-content\/uploads\/2025\/10\/Lab-manager-300x300.jpg 300w, https:\/\/sofiatechlabs.bg\/wp-content\/uploads\/2025\/10\/Lab-manager-150x150.jpg 150w\" sizes=\"(max-width: 395px) 100vw, 395px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-1b9d20b e-con-full e-flex e-con e-child\" data-id=\"1b9d20b\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-3a49d72 elementor-widget elementor-widget-heading\" data-id=\"3a49d72\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h5 class=\"elementor-heading-title elementor-size-default\">Prof. DSc. Ivan Atanassov, corr. member of BAS<\/h5>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-f7e3cc2 elementor-widget elementor-widget-text-editor\" data-id=\"f7e3cc2\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p><strong>Scientific fields:<\/strong><\/p>\n<p>molecular genetics, gene cloning, characterization and expression, recombinant proteins, molecular markers, plant genetic resources, and plant biotechnology.<br \/><strong>Achievements:<\/strong><\/p>\n<p>Over 90 published articles and more than 20 completed projects in the fields of molecular genetics and plant biotechnology.<\/p>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-9b6d59c e-con-full e-flex e-con e-parent\" data-id=\"9b6d59c\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;motion_fx_motion_fx_mouse&quot;:&quot;yes&quot;,&quot;motion_fx_mouseTrack_effect&quot;:&quot;yes&quot;,&quot;motion_fx_mouseTrack_speed&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;size&quot;:1,&quot;sizes&quot;:[]}}\">\n\t\t<div class=\"elementor-element elementor-element-120f531 e-con-full e-flex e-con e-child\" data-id=\"120f531\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t<div class=\"elementor-element elementor-element-9d0b6c5 e-flex e-con-boxed e-con e-child\" data-id=\"9d0b6c5\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-13cdcfe e-con-full banner-main e-flex e-con e-child\" data-id=\"13cdcfe\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-676a0b8 elementor-widget elementor-widget-heading\" data-id=\"676a0b8\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<div class=\"elementor-heading-title elementor-size-default\">For any other questions and services, contact us<\/div>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-4f96b51 all-button-svg elementor-align-center elementor-widget elementor-widget-button\" data-id=\"4f96b51\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-sm\" href=\"https:\/\/sofiatechlabs.bg\/en\/contacts\/\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t<span class=\"elementor-button-icon\">\n\t\t\t\t<svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"16.914\" height=\"25.828\" viewBox=\"0 0 16.914 25.828\"><g id=\"Group_100\" data-name=\"Group 100\" transform=\"translate(-5668 2129.914) rotate(180)\"><g id=\"Ellipse_4\" data-name=\"Ellipse 4\" transform=\"translate(-5676 2113)\" fill=\"none\" stroke=\"#000\" stroke-width=\"2\"><circle cx=\"4\" cy=\"4\" r=\"4\" stroke=\"none\"><\/circle><circle cx=\"4\" cy=\"4\" r=\"3\" fill=\"none\"><\/circle><\/g><line id=\"Line_3\" data-name=\"Line 3\" x1=\"9\" y2=\"9\" transform=\"translate(-5683.5 2105.5)\" fill=\"none\" stroke=\"#000\" stroke-linecap=\"round\" stroke-width=\"2\"><\/line><line id=\"Line_4\" data-name=\"Line 4\" x1=\"9\" y1=\"9\" transform=\"translate(-5683.5 2119.5)\" fill=\"none\" stroke=\"#000\" stroke-linecap=\"round\" stroke-width=\"2\"><\/line><\/g><\/svg>\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\">Requests<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t","protected":false},"featured_media":0,"parent":0,"template":"","format":"standard","class_list":["post-5183","labs","type-labs","status-publish","format-standard","hentry"],"acf":[],"_links":{"self":[{"href":"https:\/\/sofiatechlabs.bg\/en\/wp-json\/wp\/v2\/labs\/5183","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/sofiatechlabs.bg\/en\/wp-json\/wp\/v2\/labs"}],"about":[{"href":"https:\/\/sofiatechlabs.bg\/en\/wp-json\/wp\/v2\/types\/labs"}],"version-history":[{"count":9,"href":"https:\/\/sofiatechlabs.bg\/en\/wp-json\/wp\/v2\/labs\/5183\/revisions"}],"predecessor-version":[{"id":5273,"href":"https:\/\/sofiatechlabs.bg\/en\/wp-json\/wp\/v2\/labs\/5183\/revisions\/5273"}],"wp:attachment":[{"href":"https:\/\/sofiatechlabs.bg\/en\/wp-json\/wp\/v2\/media?parent=5183"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}